Topical Trametinib for Agminated Spitz Nevi Harboring HRAS Mutation

Authors

Lauren Parsons, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Alice Chen, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Brooke Bertus, Department of Dermatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Colleen Beatty, Department of Dermatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Julian Stashower, Department of Dermatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Patrick Tomboc, Department of Pediatrics- Pediatric Blood & Cancer Center, West Virginia University, Morgantown, West Virginia, USA.
Sebastian Brooke, Division of Plastic Surgery, West Virginia University, Morgantown, West Virginia, USA.
Zachary Zinn, Department of Dermatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.

Document Type

Journal Article

Publication Date

2-19-2025

Journal

Pediatric dermatology

DOI

10.1111/pde.15903

Keywords

agminated spitz nevus; dermatology; male; nevus spilus; skin diseases

Abstract

The treatment of agminated Spitz nevi can be challenging due to the potential for disfigurement in cosmetically sensitive areas. We report the case of a pediatric patient with progressive agminated Spitz nevi arising from a nevus spilus on the face with an associated pathogenic HRAS p.G13R mutation revealed on next-generation sequencing (NGS). The patient was treated with compounded topical trametinib 1% cream and demonstrated significant clinical improvement following 12 weeks of twice-daily treatment. Our case highlights the potential role of MEK inhibition as a targeted, non-surgical treatment for HRAS-mutated agminated Spitz nevi and adds to the growing understanding of their genetic etiology.

APA Citation

Parsons, Lauren; Chen, Alice; Bertus, Brooke; Beatty, Colleen; Stashower, Julian; Tomboc, Patrick; Brooke, Sebastian; and Zinn, Zachary, "Topical Trametinib for Agminated Spitz Nevi Harboring HRAS Mutation" (2025). GW Authored Works. Paper 6551.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/6551

Department

School of Medicine and Health Sciences Student Works