Prostate Luminal Cell Plasticity and Cancer

Authors

Emily C. Williams, Department of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA; The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Maho Shibata, Department of Anatomy and Cell Biology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA; The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: mshibata@gwu.edu.

Document Type

Journal Article

Publication Date

12-25-2024

Journal

Cancer letters

DOI

10.1016/j.canlet.2024.217430

Keywords

Prostate cancer; plasticity; prostate development; transdifferentiation

Abstract

Cellular plasticity in prostate cancer promotes treatment resistance. Several independent studies have used mouse models, single-cell RNA sequencing, and genetic lineage tracing approaches to characterize cellular differentiation and plasticity during prostate organogenesis, homeostasis and androgen-mediated tissue regeneration. We review these findings and recent work using immune-competent genetically-engineered mouse models to characterize cellular plasticity and clonal dynamic changes during prostate cancer progression. Collectively these studies highlight the influence of the tumor microenvironment and the function of epigenetic regulators in promoting cellular plasticity. How the epigenetic alternations that promote cell plasticity affect tumor immunogenicity remains an active area of research with implications for disease treatment.

APA Citation

Williams, Emily C. and Shibata, Maho, "Prostate Luminal Cell Plasticity and Cancer" (2024). GW Authored Works. Paper 6100.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/6100

Department

Anatomy and Regenerative Biology