Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease
Journal of Parkinson's disease
Parkinson’s disease; Restless legs; periodic leg movements in sleep
BACKGROUND: The association between restless legs syndrome (RLS) and Parkinson's disease (PD) remains controversial, with epidemiologic and descriptive evidence suggesting some potential overlap while mechanistic/genetic studies suggesting relative independence of the conditions. OBJECTIVE: To examine a known, objectively measured endophenotype for RLS, periodic leg movements (PLMS) in sleep, in patients with PD and relate that objective finding to restless legs symptoms. METHODS: We performed polysomnography for one (n = 8) or two (n = 67) consecutive nights in 75 PD patients and examined the association of PLMS with restless legs symptoms. RESULTS: We found no association between restless legs symptoms and PLMS in PD. Prevalence of both was similar to data reported previously in other PD samples. CONCLUSION: We interpret these results as suggesting that restless legs symptoms in PD patients may represent a different phenomenon and pathophysiology than RLS in the non-PD population.
Bliwise, Donald L.; Karroum, Elias G.; Greer, Sophia A.; Factor, Stewart A.; and Trotti, Lynn Marie, "Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease" (2022). GW Authored Works. Paper 593.