Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory

Authors

Hua Xie, Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.
Venkata Sita Illapani, Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.
Lauren T. Reppert, Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.
Xiaozhen You, Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.
Manu Krishnamurthy, Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.
Yutong Bai, Department of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, South Korea.
Madison M. Berl, Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.
William D. Gaillard, Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.
Seok-Jun Hong, Department of Biomedical Engineering, Sungkyunkwan University, Suwon 16419, South Korea.
Leigh N. Sepeta, Center for Neuroscience Research, Children's National Research Institute, Children's National Hospital, Washington, D.C. 20010.

Document Type

Journal Article

Publication Date

10-29-2024

Journal

Proceedings of the National Academy of Sciences of the United States of America

Volume

121

Issue

44

DOI

10.1073/pnas.2403015121

Keywords

development; episodic memory; functional connectivity; gradient; hippocampus

Abstract

The hippocampus is functionally specialized along its longitudinal axis with intricate interactions with cortical systems, which is crucial for understanding development and cognition. Using a well-established connectopic mapping technique on two large resting-state functional MRI datasets, we systematically quantified topographic organization of the hippocampal functional connectivity (hippocampal gradient) and its cortical interaction in developing brains. We revealed hippocampal functional hierarchy within the large-scale cortical brain systems, with the anterior hippocampus preferentially connected to an anterior temporal (AT) pathway and the posterior hippocampus embedded in a posterior medial (PM) pathway. We examined the developmental effects of the primary gradient and its whole-brain functional interaction. We observed increased functional specialization along the hippocampal long axis and found a general whole-brain connectivity shift from the posterior to the anterior hippocampus during development. Using phenotypic predictive modeling, we further delineated how the hippocampus is differentially integrated into the whole-brain cortical hierarchy underlying episodic memory and identified several key nodes within PM/AT systems. Our results highlight the importance of hippocampal gradient and its cortical interaction in development and for supporting episodic memory.

APA Citation

Xie, Hua; Illapani, Venkata Sita; Reppert, Lauren T.; You, Xiaozhen; Krishnamurthy, Manu; Bai, Yutong; Berl, Madison M.; Gaillard, William D.; Hong, Seok-Jun; and Sepeta, Leigh N., "Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory" (2024). GW Authored Works. Paper 5763.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5763

Department

Psychiatry and Behavioral Sciences