Title

Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease

Document Type

Journal Article

Publication Date

1-1-2022

Journal

Trends in molecular medicine

Volume

28

Issue

1

DOI

10.1016/j.molmed.2021.10.003

Keywords

adipogenesis; fibrosis; injury; muscular dystrophy; osteogenesis; stromal cells

Abstract

Aside from myofibers, numerous mononucleated cells reside in the skeletal muscle. These include the mesenchymal cells called fibro-adipogenic progenitors (FAPs), that support muscle development and regeneration in adult muscles. Recent evidence shows that defects in FAP function contributes to chronic muscle diseases and targeting FAPs offers avenues for treating these diseases.

Department

Genomics and Precision Medicine

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