Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease
Trends in molecular medicine
adipogenesis; fibrosis; injury; muscular dystrophy; osteogenesis; stromal cells
Aside from myofibers, numerous mononucleated cells reside in the skeletal muscle. These include the mesenchymal cells called fibro-adipogenic progenitors (FAPs), that support muscle development and regeneration in adult muscles. Recent evidence shows that defects in FAP function contributes to chronic muscle diseases and targeting FAPs offers avenues for treating these diseases.
Hogarth, Marshall W.; Uapinyoying, Prech; Mázala, Davi A.; and Jaiswal, Jyoti K., "Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease" (2022). GW Authored Works. Paper 496.
Genomics and Precision Medicine