Standards recommendations for the Earth BioGenome Project


Mara K.N. Lawniczak, Wellcome Sanger Institute
Richard Durbin, Wellcome Sanger Institute
Paul Flicek, Wellcome Sanger Institute
Kerstin Lindblad-Toh, Broad Institute
Xiaofeng Wei, China National Genebank
John M. Archibald, Dalhousie University
William J. Baker, Royal Botanic Gardens, Kew
Katherine Belov, Faculty of Science
Mark L. Blaxter, Wellcome Sanger Institute
Tomas Marques Bonet, Consejo Superior de Investigaciones Científicas
Anna K. Childers, USDA ARS Beltsville Agricultural Research Center
Jonathan A. Coddington, Smithsonian National Museum of Natural History
Keith A. Crandall, Milken Institute School of Public Health
Andrew J. Crawford, Universidad de Los Andes, Colombia
Robert P. Davey, Norwich Research Park
Federica Di Palma, Genome British Columbia
Qi Fang, BGI-Shenzhen
Wilfried Haerty, Norwich Research Park
Neil Hall, Genome British Columbia
Katharina J. Hoff, Universität Greifswald
Kerstin Howe, Wellcome Sanger Institute
Erich D. Jarvis, Rockefeller University
Warren E. Johnson, Conservation and Research Center (National Zoo)
Rebecca N. Johnson, Smithsonian National Museum of Natural History
Paul J. Kersey, European Bioinformatics Institute
Xin Liu, China National Genebank
Jose Victor Lopez, Nova Southeastern University
Eugene W. Myers, Max Planck Institute of Molecular Cell Biology and Genetics
Olga Vinnere Pettersson, Uppsala Universitet
Adam M. Phillippy, National Human Genome Research Institute (NHGRI)
Monica F. Poelchau, USDA ARS Beltsville Agricultural Research Center
Kim D. Pruitt, National Center for Biotechnology Information (NCBI)

Document Type

Journal Article

Publication Date



Proceedings of the National Academy of Sciences of the United States of America








Earth BioGenome Project; Ethics; Genome assembly; Genomics


A global international initiative, such as the Earth BioGenome Project (EBP), requires both agreement and coordination on standards to ensure that the collective effort generates rapid progress toward its goals. To this end, the EBP initiated five technical standards committees comprising volunteer members from the global genomics scientific community: Sample Collection and Processing, Sequencing and Assembly, Annotation, Analysis, and IT and Informatics. The current versions of the resulting standards documents are available on the EBP website, with the recognition that opportunities, technologies, and challenges may improve or change in the future, requiring flexibility for the EBP to meet its goals. Here, we describe some highlights from the proposed standards, and areas where additional challenges will need to be met.