Neonatal Botulism: A Case Series Suggesting Varied Presentations
Botulinum toxin; Botulism; Neonatal; Neuromuscular; Respiratory distress
Infantile botulism is an uncommon diagnosis and rarer still in the neonatal period. We describe three cases of neonatal-onset botulism that presented with symptoms typically (hypotonia, constipation, facial diplegia) or atypically seen in older infants (encephalopathy, seizures, and hypothermia). Our series shows a wider spectrum of clinical presentations in patients with neonatal-onset botulism. Our report also suggests that neonatal-onset botulism should be considered more broadly in the hypotonic infant, especially as the condition is treatable with intravenous botulinum-specific immune globulin.
Horvat, David E.; Eye, Philip G.; Whitehead, Mathew T.; Bharucha-Goebel, Diana; Roth, Emmeline; Anwar, Tayyba; Tsuchida, Tammy; and Kousa, Youssef A., "Neonatal Botulism: A Case Series Suggesting Varied Presentations" (2023). GW Authored Works. Paper 3490.