Dupilumab Treatment Reduces Hospitalizations in Adults with Moderate-to-Severe Atopic Dermatitis
The journal of allergy and clinical immunology. In practice
Atopic dermatitis; Dupilumab; Flares; Hospitalization; Resource utilization
BACKGROUND: Refractory disease, flares, or infections in atopic dermatitis (AD) can lead to hospitalizations. OBJECTIVE: To compare hospitalization rates among adults with moderate-to-severe AD treated with dupilumab versus control. METHODS: Data from 7 randomized, placebo-controlled trials of dupilumab (300 mg every 2 weeks [q2w] and/or weekly [qw]; with or without topical corticosteroids) were analyzed. RESULTS: Patients in the dupilumab 300 mg q2w, qw, and combined dupilumab (q2w and qw; n = 1,841) groups compared with patients in the control group (n = 1,091) had lower rates of all-cause hospitalizations (5.8, 2.7, and 3.8 events, respectively, vs 9.0 events per 100 patient-years [PY]; all P < .05 [49%, 71%, and 62% risk reduction, respectively]); AD-related hospitalizations (2.0, 0.4, 1.0 events vs 4.1 events per 100 PY; P < .05 for qw and dupilumab combined [91% and 79% risk reduction, respectively]); as well as reduced overall duration of AD-related hospitalization (10.9, 7.3, and 8.6 d vs 38.9 d per 100 PY). CONCLUSIONS: Among adults with moderate-to-severe AD, treatment with dupilumab versus control was associated with significant reductions in all-cause and AD-related hospitalization rates, and shorter duration of AD-related hospitalization.
Silverberg, Jonathan I.; Rubini, Norma P.; Pires, Mario C.; Rossi, Ana B.; Zhang, Annie; Chen, Zhen; Levit, Noah A.; Chao, Jingdong; Shumel, Brad; and Bégo-Le Bagousse, Gaëlle, "Dupilumab Treatment Reduces Hospitalizations in Adults with Moderate-to-Severe Atopic Dermatitis" (2022). GW Authored Works. Paper 267.