"Nasal Allergen Challenge (NAC): Practical Aspects and Applications from an EU/US perspective: A Workgroup Report of the AAAAI Rhinitis, Rhinosinusitis and Ocular Allergy Committee"
The Journal of allergy and clinical immunology
Allergen; challenge; nasal; obstruction; symptoms
Nasal allergen challenge (NAC) is applied in a variety of settings (research centres, specialty clinics and hospitals) as a useful diagnostic and research tool. NAC is indicated for diagnosis of seasonal and perennial allergic rhinitis, local allergic rhinitis, occupational rhinitis, to design the composition of allergen immunotherapy in polysensitized patients and to investigate the physio-pathological mechanisms of nasal diseases. NAC is currently a safe and reproducible technique, although it is time and resource consuming. NAC can be performed by a variety of methods, but the lack of a uniform technique for performing and recording the outcomes, represents a challenge for those considering NAC as a clinical tool in the office. The availability of standardized allergens for NAC is also different in each country. The objective of this workgroup report is to review the current information about NAC, focusing on the practical aspects and application for diagnosis of difficult rhinitis phenotypes (e.g. local allergic rhinitis, occupational rhinitis), taking into account the particular context of practice in the United States and the European Union.
Cho, Seong H.; Nanda, Anil; Keswani, Anjeni; Adinoff, Allen; Baroody, Fuad M.; Bernstein, Jonathan A.; Gherasim, Alina; Han, Joseph K.; Koepke, Jerald W.; Ledford, Dennis K.; Pepper, Amber N.; Rondón, Carmen; Schiffman, Amy; Wagenmann, Martin; and Campo, Paloma, ""Nasal Allergen Challenge (NAC): Practical Aspects and Applications from an EU/US perspective: A Workgroup Report of the AAAAI Rhinitis, Rhinosinusitis and Ocular Allergy Committee"" (2023). GW Authored Works. Paper 2366.