Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder

Authors

George V. Tetz, Human Microbiology Institute, New York, NY, USA.
Kristina M. Kardava, Human Microbiology Institute, New York, NY, USA.
Maria F. Vecherkovskaya, Human Microbiology Institute, New York, NY, USA.
Michael D. Tsifansky, Department of Pediatrics, George Washington University (GWU), Washington, DC, USA.
Victor V. Tetz, Human Microbiology Institute, New York, NY, USA.

Document Type

Journal Article

Publication Date

1-1-2023

Journal

Urology case reports

Volume

46

DOI

10.1016/j.eucr.2022.102312

Keywords

Antibiotics; AtbFinder; Drug resistant; Susceptibility testing; Urinary tract infection

Abstract

We report the case of a 46-year-old patient who, after renal cancer surgery, developed a recurrent urinary tract infection that lasted for more than 2 years. Despite repeated antibiotic courses, including broad-spectrum drugs chosen using conventional antibiotic susceptibility testing, multiple reinfections followed. The patient was successfully treated once antibiotics were selected with AtbFinder. Unlike routine antimicrobial susceptibility methods, which select antibiotics effective only against a "lead bacterial pathogen," AtbFinder identifies antibiotics that target the mixture of bacteria at the infection site. This case demonstrates the ability of AtbFinder to successfully select antibiotics for the treatment of relapsing urinary tract infections.

APA Citation

Tetz, George V.; Kardava, Kristina M.; Vecherkovskaya, Maria F.; Tsifansky, Michael D.; and Tetz, Victor V., "Treatment of chronic relapsing urinary tract infection with antibiotics selected by AtbFinder" (2023). GW Authored Works. Paper 2321.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/2321

Department

Pediatrics