Clinical approach to vasoplegia in the transplant patient from the Pediatric Heart Transplant Society


Shriprasad R. Desphpande, Department of Cardiology and Cardiovascular Surgery, Children's National Hospital, The George Washington University, Washington, DC, USA.
David W. Bearl, Department of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee, USA.
Pirooz Eghtesady, Section of Pediatric Cardiothoracic Surgery, St Louis Children's Hospital and School of Medicine, Washington University, St Louis, Michigan, USA.
Heather T. Henderson, Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA.
Scott Auerbach, Pediatrics, Division of Cardiology, University of Colorado, Denver Anschutz Medical Campus, Children's Hospital Colorado Aurora, Aurora, Colorado, USA.
Aamir Jeewa, Department of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada.
Neha Bansal, Children's Hospital at Montefiore, Bronx, New York, USA.
Shahnawaz Amdani, Cleveland Clinic Children's, Cleveland, Ohio, USA.
Marc E. Richmond, Division of Pediatric Cardiology, Department of Pediatrics, Columbia University College of Physician and Surgeons, Morgan Stanley Children's Hospital, New York, New York, USA.
Loren D. Sacks, Pediatric Cardiology, Stanford University School of Medicine, Palo Alto, California, USA.
Renata Shih, Congenital Heart Center, Division of Pediatric Cardiology, University of Florida, Gainesville, Florida, USA.
Madeleine Townsend, Cleveland Clinic Children's, Cleveland, Ohio, USA.
Jennifer Conway, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada.

Document Type

Journal Article

Publication Date



Pediatric transplantation








pediatric heart transplant; post-operative; vasoplegia


This manuscript outlines a clinical approach to vasoplegia incorporating the current state of knowledge regarding vasoplegia in pediatric patients immediately post-transplant and to identify modifiable factors both pre- and post-transplant that may reduce post-operative morbidity, end-organ dysfunction, and mortality. Centers participating in the Pediatric Heart Transplant Society (PHTS) were asked to provide their internal protocols and rationale for vasoplegia management, and applicable adult and pediatric data were reviewed. The authors synthesized the above protocols and literature into the following description of clinical approaches to vasoplegia highlighting areas of both broad consensus and of significant practice variation.