The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Authors

Jena V. Lilly, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jo Lynne Rokita, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jennifer L. Mason, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tatiana Patton, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Stephanie Stefankiewiz, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
David Higgins, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Gerri Trooskin, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Carina A. Larouci, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kamnaa Arya, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Elizabeth Appert, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Allison P. Heath, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Yuankun Zhu, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Miguel A. Brown, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Bo Zhang, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Bailey K. Farrow, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Shannon Robins, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Allison M. Morgan, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Thinh Q. Nguyen, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Elizabeth Frenkel, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kaitlin Lehmann, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Emily Drake, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Catherine Sullivan, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alexa Plisiewicz, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Noel Coleman, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Luke Patterson, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Mateusz Koptyra, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zeinab Helili, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Nicholas Van Kuren, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Nathan Young, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Meen Chul Kim, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Christopher Friedman, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alex Lubneuski, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Document Type

Journal Article

Publication Date

11-3-2022

Journal

Neoplasia (New York, N.Y.)

Volume

35

DOI

10.1016/j.neo.2022.100846

Keywords

Biospecimens; Collaborative international research infrastructure; Longitudinal clinical data; Molecular clinical trials; Multi-omic data; Pediatric brain tumors

Abstract

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for > 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors.

Department

Genomics and Precision Medicine

Share

COinS