The IPTA Nashville consensus conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: II-consensus guidelines for prevention
The International Pediatric Transplant Association (IPTA) convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post-transplant lymphoproliferative disorder after solid organ transplantation in children. In this report from the Prevention Working Group, we reviewed the existing literature regarding immunoprophylaxis and chemoprophylaxis, and pre-emptive strategies. While the group made a strong recommendation for pre-emptive reduction of immunosuppression at the time of EBV DNAemia (low to moderate evidence), no recommendations for use could be made for any prophylactic strategy or alternate pre-emptive strategy, largely due to insufficient or conflicting evidence. Current gaps and future research priorities are highlighted.
Green, Michael; Squires, James E.; Chinnock, Richard E.; Comoli, Patrizia; Danziger-Isakov, Lara; Dulek, Daniel E.; Esquivel, Carlos O.; Höcker, Britta; L'Huillier, Arnaud G.; Mazariegos, George Vincent; Visner, Gary A.; Bollard, Catherine M.; Dipchand, Anne I.; Ferry, Judith A.; Gross, Thomas G.; Hayashi, Robert; Maecker-Kolhoff, Britta; Marks, Stephen; Martinez, Olivia M.; Metes, Diana M.; Michaels, Marian G.; Preiksaitis, Jutta; Smets, Françoise; Swerdlow, Stephen H.; Trappe, Ralf U.; Wilkinson, James D.; Allen, Upton; Webber, Steven A.; and Dharnidharka, Vikas R., "The IPTA Nashville consensus conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: II-consensus guidelines for prevention" (2022). GW Authored Works. Paper 1951.