Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches
HIV; allogeneic; cancer; expansion; gammadelta cells; immunotherapy; infectious diseases
Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases. γδ T cells are excellent candidates for cellular immunotherapy due to their unique properties to recognize and destroy tumors or infected cells. They do not depend on the recognition of a single antigen but rather a broad-spectrum of diverse ligands through expression of various cytotoxic receptors. In this manuscript, we review major characteristics of the most abundant circulating γδ subpopulation, Vδ2 T cells, their immunotherapeutic potential, recent advances in expansion protocols, their preclinical and clinical applications for several infectious diseases and malignancies, and how additional modulation could enhance their therapeutic potential.
Sanz, Marta; Mann, Brendan T.; Chitrakar, Alisha; and Soriano-Sarabia, Natalia, "Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches" (2022). GW Authored Works. Paper 1946.
Microbiology, Immunology, and Tropical Medicine