Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches

Document Type

Journal Article

Publication Date

11-11-2022

Journal

Cells

Volume

11

Issue

22

DOI

10.3390/cells11223572

Keywords

HIV; allogeneic; cancer; expansion; gammadelta cells; immunotherapy; infectious diseases

Abstract

Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases. γδ T cells are excellent candidates for cellular immunotherapy due to their unique properties to recognize and destroy tumors or infected cells. They do not depend on the recognition of a single antigen but rather a broad-spectrum of diverse ligands through expression of various cytotoxic receptors. In this manuscript, we review major characteristics of the most abundant circulating γδ subpopulation, Vδ2 T cells, their immunotherapeutic potential, recent advances in expansion protocols, their preclinical and clinical applications for several infectious diseases and malignancies, and how additional modulation could enhance their therapeutic potential.

Department

Microbiology, Immunology, and Tropical Medicine

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