Longitudinal Blood Pressure Patterns from Mid- to Late Life and Late-Life Hearing Loss in the Atherosclerosis Risk in Communities Study
Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Cardiovascular; Epidemiology; Risk factors; Sensory
Background: Hearing loss is prevalent and associated with adverse functional outcomes in older adults. Prevention thus has far-reaching implications, yet few modifiable risk factors have been identified. Hypertension may contribute to age-related hearing loss, but epidemiologic evidence is mixed. We studied a prospective cohort of 3343 individuals from the Atherosclerosis Risk in Communities study, aged 44-65 years at baseline with up to 30 years of follow-up. Methods: Hearing was assessed in late life (2016-2017) using a better-ear audiometric pure tone average (0.5, 1, 2, 4 kHz) and the Quick Speech-in-Noise (QuickSIN) test. Hypertension was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or antihypertensive medication use. Midlife hypertension was defined by hypertension at 2 consecutive visits between 1987-1989 and 1996-1998. Late-life hypertension was defined in 2016-2017. Late-life low blood pressure was defined as a systolic blood pressure less than 90 mmHg or diastolic blood pressure less than 60 mmHg, irrespective of antihypertensive medication use. Associations between blood pressure patterns from mid- to late life and hearing outcomes were assessed using multivariable-adjusted linear regression. Results: Compared to persistent normotension, persistent hypertension from mid- to late life was associated with worse central auditory processing (difference in QuickSIN score = -0.66 points, 95% CI: -1.14, -0.17) but not with audiometric hearing. Conclusions: Participants with persistent hypertension had poorer late-life central auditory processing. These findings suggest that hypertension may be more strongly related to hearing-related changes in the brain than in the cochlea.
Ting, James; Jiang, Kening; Du, Simo; Betz, Joshua; Reed, Nicholas; Power, Melinda C.; Gottesman, Rebecca; Richey Sharrett, A.; Griswold, Michael; Walker, Keenan A.; Miller, Edgar R.; Lin, Frank R.; and Deal, Jennifer A., "Longitudinal Blood Pressure Patterns from Mid- to Late Life and Late-Life Hearing Loss in the Atherosclerosis Risk in Communities Study" (2022). GW Authored Works. Paper 165.