Chronic Oxidative Stress as a Marker of Long-term Radiation-Induced Cardiovascular Outcomes in Breast Cancer
Journal of cardiovascular translational research
Biomarkers; Breast cancer; Cardiovascular disease; Inflammation; Oxidative stress; Radiation
While biomarkers have been proposed to identify individuals at risk for radiation-induced cardiovascular disease (RICVD), little is known about long-term associations with cardiac events. We examined associations of biomarkers of oxidative stress (myeloperoxidase, growth differentiation factor-15, 8-hydroxy-2'-deoxyguanosine [8-OH-dG], placental growth factor), cardiac injury (troponin I, cystatin-C), inflammation (interleukin-6, C-reactive protein), and myocardial fibrosis (transforming growth factor-ß) with long-term RICVD in breast cancer (BC) survivors. We conducted a nested case-control study within the Women's Health Initiative of postmenopausal women with incident BC stages I-III, who received radiation and had pre- and post-BC diagnosis serum samples. Cases (n = 55) were defined as developing incident, physician-adjudicated myocardial infarction, coronary heart disease death, other CVD death, heart failure, or stroke after BC. Cases were matched to three controls (n = 158). After adjustment, a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting oxidative DNA damage may be a putative pathway for RICVD.
Vasbinder, Alexi; Cheng, Richard K.; Heckbert, Susan R.; Thompson, Hilaire; Zaslavksy, Oleg; Chlebowski, Rowan T.; Shadyab, Aladdin H.; Johnson, Lisa; Wactawski-Wende, Jean; Wells, Gretchen; Yung, Rachel; Martin, Lisa Warsinger; Paskett, Electra D.; and Reding, Kerryn, "Chronic Oxidative Stress as a Marker of Long-term Radiation-Induced Cardiovascular Outcomes in Breast Cancer" (2022). GW Authored Works. Paper 1581.