Chronic Oxidative Stress as a Marker of Long-term Radiation-Induced Cardiovascular Outcomes in Breast Cancer

Alexi Vasbinder, Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, USA.
Richard K. Cheng, Division of Cardiology, Department of Medicine, University of Washington Medical Center, Seattle, USA.
Susan R. Heckbert, Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA.
Hilaire Thompson, Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, USA.
Oleg Zaslavksy, Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, USA.
Rowan T. Chlebowski, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, USA.
Aladdin H. Shadyab, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, USA.
Lisa Johnson, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, USA.
Jean Wactawski-Wende, Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University of Buffalo, Buffalo, USA.
Gretchen Wells, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington-Fayette, USA.
Rachel Yung, Division of Medical Oncology, University of Washington, Seattle, USA.
Lisa Warsinger Martin, Division of Cardiology, School of Medicine and Health Sciences, George Washington University, Seattle, USA.
Electra D. Paskett, Comprehensive Cancer Center, Department of Medicine, The Ohio State University, Columbus, USA.
Kerryn Reding, Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, USA. kreding@uw.edu.

Document Type

Journal Article

Publication Date

9-30-2022

Journal

Journal of cardiovascular translational research

DOI

10.1007/s12265-022-10320-2

Keywords

Biomarkers; Breast cancer; Cardiovascular disease; Inflammation; Oxidative stress; Radiation

Abstract

While biomarkers have been proposed to identify individuals at risk for radiation-induced cardiovascular disease (RICVD), little is known about long-term associations with cardiac events. We examined associations of biomarkers of oxidative stress (myeloperoxidase, growth differentiation factor-15, 8-hydroxy-2'-deoxyguanosine [8-OH-dG], placental growth factor), cardiac injury (troponin I, cystatin-C), inflammation (interleukin-6, C-reactive protein), and myocardial fibrosis (transforming growth factor-ß) with long-term RICVD in breast cancer (BC) survivors. We conducted a nested case-control study within the Women's Health Initiative of postmenopausal women with incident BC stages I-III, who received radiation and had pre- and post-BC diagnosis serum samples. Cases (n = 55) were defined as developing incident, physician-adjudicated myocardial infarction, coronary heart disease death, other CVD death, heart failure, or stroke after BC. Cases were matched to three controls (n = 158). After adjustment, a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting oxidative DNA damage may be a putative pathway for RICVD.

Department

Medicine

Link to Full Text

Share

COinS