Defying convention in the time of COVID-19: Insights into the role of γδ T cells
Frontiers in immunology
COVID-19; SARS-CoV-2; aminobisphosphonates COVID-19; gamma delta (γδ) T cells; innate immunity
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a complex disease which immune response can be more or less potent. In severe cases, patients might experience a cytokine storm that compromises their vital functions and impedes clearance of the infection. Gamma delta (γδ) T lymphocytes have a critical role initiating innate immunity and shaping adaptive immune responses, and they are recognized for their contribution to tumor surveillance, fighting infectious diseases, and autoimmunity. γδ T cells exist as both circulating T lymphocytes and as resident cells in different mucosal tissues, including the lungs and their critical role in other respiratory viral infections has been demonstrated. In the context of SARS-CoV-2 infection, γδ T cell responses are understudied. This review summarizes the findings on the antiviral role of γδ T cells in COVID-19, providing insight into how they may contribute to the control of infection in the mild/moderate clinical outcome.
Sanz, Marta; Mann, Brendan T.; Chitrakar, Alisha; and Soriano-Sarabia, Natalia, "Defying convention in the time of COVID-19: Insights into the role of γδ T cells" (2022). GW Authored Works. Paper 1488.
Microbiology, Immunology, and Tropical Medicine