Prostate organogenesis

Document Type

Journal Article

Publication Date

6-15-2022

Journal

Development (Cambridge, England)

Volume

149

Issue

12

DOI

10.1242/dev.200394

Keywords

Androgen receptor; Androgen signaling; Cellular heterogeneity; Prostate culture; Prostate development; Prostate organogenesis

Abstract

Prostate organogenesis begins during embryonic development and continues through puberty when the prostate becomes an important exocrine gland of the male reproductive system. The specification and growth of the prostate is regulated by androgens and is largely a result of cell-cell communication between the epithelium and mesenchyme. The fields of developmental and cancer biology have long been interested in prostate organogenesis because of its relevance for understanding prostate diseases, and research has expanded in recent years with the advent of novel technologies, including genetic-lineage tracing, single-cell RNA sequencing and organoid culture methods, that have provided important insights into androgen regulation, epithelial cell origins and cellular heterogeneity. We discuss these findings, putting them into context with what is currently known about prostate organogenesis.

Department

Anatomy and Regenerative Biology

Link to Full Text

Share

COinS