Nfkbid-mediated humoral immunity during secondary toxoplasmosis

Authors

Imtiaz A. Khan, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA. Electronic address: Imti56@gwu.edu.
Magali Moretto, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA. Electronic address: morettom@gwu.edu.

Document Type

Journal Article

Publication Date

4-1-2022

Journal

Trends in parasitology

Volume

38

Issue

4

DOI

10.1016/j.pt.2022.01.010

Keywords

B cells; CD8 T cells; Nfkbid; Toxoplasma gondii; vaccine

Abstract

Vaccine-mediated immunity to parasites has not been achieved. Immune C57BL/6 mice are susceptible to secondary Toxoplasma gondii infection. Using a forward genetics approach, Souza et al. identify Nfkbid as an important factor for the regulation of B cell immunity during secondary Toxoplasma infection and protection against rechallenge.

APA Citation

Khan, Imtiaz A. and Moretto, Magali, "Nfkbid-mediated humoral immunity during secondary toxoplasmosis" (2022). GW Authored Works. Paper 101.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/101

Department

Microbiology, Immunology, and Tropical Medicine