Title

Nfkbid-mediated humoral immunity during secondary toxoplasmosis

Document Type

Journal Article

Publication Date

4-1-2022

Journal

Trends in parasitology

Volume

38

Issue

4

DOI

10.1016/j.pt.2022.01.010

Keywords

B cells; CD8 T cells; Nfkbid; Toxoplasma gondii; vaccine

Abstract

Vaccine-mediated immunity to parasites has not been achieved. Immune C57BL/6 mice are susceptible to secondary Toxoplasma gondii infection. Using a forward genetics approach, Souza et al. identify Nfkbid as an important factor for the regulation of B cell immunity during secondary Toxoplasma infection and protection against rechallenge.

Department

Microbiology, Immunology, and Tropical Medicine

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