Nfkbid-mediated humoral immunity during secondary toxoplasmosis
Trends in parasitology
B cells; CD8 T cells; Nfkbid; Toxoplasma gondii; vaccine
Vaccine-mediated immunity to parasites has not been achieved. Immune C57BL/6 mice are susceptible to secondary Toxoplasma gondii infection. Using a forward genetics approach, Souza et al. identify Nfkbid as an important factor for the regulation of B cell immunity during secondary Toxoplasma infection and protection against rechallenge.
Khan, Imtiaz A. and Moretto, Magali, "Nfkbid-mediated humoral immunity during secondary toxoplasmosis" (2022). GW Authored Works. Paper 101.
Microbiology, Immunology, and Tropical Medicine