School of Medicine and Health Sciences Poster Presentations
Assessing recurrence of Atrial Fibrillation using inflammatory biomarkers
Poster Number
145
Document Type
Poster
Status
Medical Student
Abstract Category
Cardiology/Cardiovascular Research
Keywords
Atrial Fibrillation, Inflammation, Cardiology, Biomarkers
Publication Date
Spring 2018
Abstract
Atrial fibrillation (AF) is a condition where a group of conductile cells in the atria begin to signal independently of the pacemaking cells of the heart. This leads to a rapidly irregular heart rate resulting in an uncoordinated flow of blood through the heart, which increases the risk of life-threatening thromboembolic events. Patients who are candidates for surgery are treated via catheter ablation targeting the aberrant group of cells which cuts the circuit and restores a normal sinus rhythm. About 30% of patients that undergo this treatment have their AF successfully abolished, only for it to reoccur. We aimed to assess the role of inflammatory biomarkers and how they predict the reoccurrence of AF. We recruited 10 patients with AF and isolated peripheral blood mononuclear cells (PBMC) before, one week after, and one month after the catheter ablation. PBMCs were then cultured for 24 hours and their secretions collected and analyzed using ELISA and Multiplex-luminex kits. The future direction of the study is to use a comprehensive panel of biomarkers in order to identify inflammation-dependent AF and to predict AF recurrence in patients post-ablation.
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Open Access
1
Assessing recurrence of Atrial Fibrillation using inflammatory biomarkers
Atrial fibrillation (AF) is a condition where a group of conductile cells in the atria begin to signal independently of the pacemaking cells of the heart. This leads to a rapidly irregular heart rate resulting in an uncoordinated flow of blood through the heart, which increases the risk of life-threatening thromboembolic events. Patients who are candidates for surgery are treated via catheter ablation targeting the aberrant group of cells which cuts the circuit and restores a normal sinus rhythm. About 30% of patients that undergo this treatment have their AF successfully abolished, only for it to reoccur. We aimed to assess the role of inflammatory biomarkers and how they predict the reoccurrence of AF. We recruited 10 patients with AF and isolated peripheral blood mononuclear cells (PBMC) before, one week after, and one month after the catheter ablation. PBMCs were then cultured for 24 hours and their secretions collected and analyzed using ELISA and Multiplex-luminex kits. The future direction of the study is to use a comprehensive panel of biomarkers in order to identify inflammation-dependent AF and to predict AF recurrence in patients post-ablation.