School of Medicine and Health Sciences Poster Presentations

Title

PPARGC1A and IGF Polymorphisms Correlate with Greater Strength Performance in Healthy Young Adult Caucasian Cohorts

Poster Number

119

Document Type

Poster

Status

Medical Student

Abstract Category

Basic Biomedical Sciences

Keywords

IGF-1, PPARGC1A, Anaerobic performance, VO2max, isometric strength

Publication Date

Spring 2018

Abstract

Background

Recent studies show single nucleotide polymorphisms (SNPs) in PPARGC1A (coding for PGC-1 α) and Insulin-like Growth Factor 1 (IGF-1) genes correlate with greater power sport performance in professional athletes.1,2 In rs8192678 on the PPARGC1A gene, a substitution causes lower PGC-1α expression and reduced performance.1 For IGF-1 rs7136446 polymorphism, GG homozygosity correlates with greater expression of IGF-1 and increased maximal force.3

Objective

The purpose of our study was to investigate whether rs8192678 or rs7136446 predict strength performance in young Caucasian adults who are not elite athletes.

Methods

Different measurements of strength were obtained from two cohorts of young adult Caucasian individuals, Functional Single Nucleotide Polymorphism Associated with Human Muscle Size and Strength (FAMuSS) and a sub-cohort of the Assessing Inherited Markers of Metabolic Syndrome in the Young (AIMMY) University of Calgary cohort.IGF-1 in PPARGC1A was not in Hardy Weinberg equilibrium, but the distribution of alleles was similar to a prior study of IGF1 gene variants4. Analysis of covariance (ANCOVA) models were utilized to analyze for genotype-phenotype associations.

Results

Ser/Ser genotype females had a greater percentage change in 1-RM strength in the dominant (D) arm, but no statistical significance was found regarding baseline strength, percentage change in the non-dominant (ND) arm, or percentage change of isometric strength. In male participants, the Gly/Gly genotype was more beneficial to baseline 1-RM strength. Our study found no significant associations for variants of rs8192678 with VO2 max.

Discussion

We found male G/G individuals had a greater percent change in isometric strength than heterozygous individuals. Females with at least one G allele had a greater baseline isometric strength and VO2 max. Our results support earlier findings of correlation with greater maximal force production3 and indicate a sexually dimorphic effect. Variation in rs8192678 and rs7136446 may help predict individual response to an exercise program, particularly in females.

References:

1) Gineviciene V, Jakaitiene A, Aksenow MO, et al. Association analysis of ACE, ACTN3 and PPARGC1A gene polymorphisms in two cohorts of European strength and power athletes. Biol Sport 2016; 33(3):199-206.

2) Ben-Zaken S, Malach S, Meckel Y, et al. Frequency of the IGF A/G rs7136446 Polymorphism and Athletic Performance. Acta Kinesiologiae Universitatis Tartuensis 2016; 22: 36-46.

3) Huuskonen A, Lappalainen J, Oksala N, et al. Common Genetic Variation in the IGF1 Associates with Maximal Force Output. Medicine & Science in Sports & Exercise 2011; 43: 2368-2374.

4) Rzehak P, Grote V, Lattka E, et al. Associations of IGF-1 gene variants and milk protein intake with IGF-1 concentrations in infants at age 6 months- results from a randomized clinical trial. Growth Hormone & IGF Research 2013; 23: 149-158.

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PPARGC1A and IGF Polymorphisms Correlate with Greater Strength Performance in Healthy Young Adult Caucasian Cohorts

Background

Recent studies show single nucleotide polymorphisms (SNPs) in PPARGC1A (coding for PGC-1 α) and Insulin-like Growth Factor 1 (IGF-1) genes correlate with greater power sport performance in professional athletes.1,2 In rs8192678 on the PPARGC1A gene, a substitution causes lower PGC-1α expression and reduced performance.1 For IGF-1 rs7136446 polymorphism, GG homozygosity correlates with greater expression of IGF-1 and increased maximal force.3

Objective

The purpose of our study was to investigate whether rs8192678 or rs7136446 predict strength performance in young Caucasian adults who are not elite athletes.

Methods

Different measurements of strength were obtained from two cohorts of young adult Caucasian individuals, Functional Single Nucleotide Polymorphism Associated with Human Muscle Size and Strength (FAMuSS) and a sub-cohort of the Assessing Inherited Markers of Metabolic Syndrome in the Young (AIMMY) University of Calgary cohort.IGF-1 in PPARGC1A was not in Hardy Weinberg equilibrium, but the distribution of alleles was similar to a prior study of IGF1 gene variants4. Analysis of covariance (ANCOVA) models were utilized to analyze for genotype-phenotype associations.

Results

Ser/Ser genotype females had a greater percentage change in 1-RM strength in the dominant (D) arm, but no statistical significance was found regarding baseline strength, percentage change in the non-dominant (ND) arm, or percentage change of isometric strength. In male participants, the Gly/Gly genotype was more beneficial to baseline 1-RM strength. Our study found no significant associations for variants of rs8192678 with VO2 max.

Discussion

We found male G/G individuals had a greater percent change in isometric strength than heterozygous individuals. Females with at least one G allele had a greater baseline isometric strength and VO2 max. Our results support earlier findings of correlation with greater maximal force production3 and indicate a sexually dimorphic effect. Variation in rs8192678 and rs7136446 may help predict individual response to an exercise program, particularly in females.

References:

1) Gineviciene V, Jakaitiene A, Aksenow MO, et al. Association analysis of ACE, ACTN3 and PPARGC1A gene polymorphisms in two cohorts of European strength and power athletes. Biol Sport 2016; 33(3):199-206.

2) Ben-Zaken S, Malach S, Meckel Y, et al. Frequency of the IGF A/G rs7136446 Polymorphism and Athletic Performance. Acta Kinesiologiae Universitatis Tartuensis 2016; 22: 36-46.

3) Huuskonen A, Lappalainen J, Oksala N, et al. Common Genetic Variation in the IGF1 Associates with Maximal Force Output. Medicine & Science in Sports & Exercise 2011; 43: 2368-2374.

4) Rzehak P, Grote V, Lattka E, et al. Associations of IGF-1 gene variants and milk protein intake with IGF-1 concentrations in infants at age 6 months- results from a randomized clinical trial. Growth Hormone & IGF Research 2013; 23: 149-158.