Milken Institute School of Public Health Poster Presentations (Marvin Center & Video)

Title

Human Evidence for Parental Glyphosate Exposure on Developmental Malformations and Neurodevelopmental Effects: Systematic Literature Review via the Navigation Guide Methodology

Poster Number

351

Document Type

Poster

Status

Graduate Student - Masters

Abstract Category

Environmental and Occupational Health

Keywords

Glyphosate, Developmental Impacts, Children

Publication Date

Spring 2018

Abstract

Background: Glyphosate is one of the most widely used pesticides on a global scale. Toxicity potential has been a controversial topic with regards to glyphosate, however some links have shown mechanistic plausibility between glyphosate and offspring defects. Objectives: Applied the Navigation Guide methodology for a systematic literature review to assess the current the literature as a means to answer if an association can be seen between glyphosate exposure from parental pesticide appliers and developmental malformations (DM)/ neurodevelopmental effects (NE) in infants.

Methods: A comprehensive search of the literature through PubMed and SCOPUS was conducted, using a set of inclusion and exclusion criteria. Risk of bias, quality of evidence and the strength of evidence were assessed for each included study.

Discussion: Six studies were ultimately included, 3 of which assessed NE as the outcome and 4 studies assessed DM as the outcome (1 study overlap). The quality of evidence was rated as “Moderate” for NE and “Low” for DM studies. Limited evidence of a statistically significant result was seen for the NE association, while a consistent statistically insignificant result was seen for the DM association.

Conclusion: This Navigation Guide based systematic literature review illustrated a “limited evidence of human toxicity” for the NE outcome and glyphosate while “insufficient evidence of human toxicity” was assessed for glyphosate and the DM outcome.

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Human Evidence for Parental Glyphosate Exposure on Developmental Malformations and Neurodevelopmental Effects: Systematic Literature Review via the Navigation Guide Methodology

Background: Glyphosate is one of the most widely used pesticides on a global scale. Toxicity potential has been a controversial topic with regards to glyphosate, however some links have shown mechanistic plausibility between glyphosate and offspring defects. Objectives: Applied the Navigation Guide methodology for a systematic literature review to assess the current the literature as a means to answer if an association can be seen between glyphosate exposure from parental pesticide appliers and developmental malformations (DM)/ neurodevelopmental effects (NE) in infants.

Methods: A comprehensive search of the literature through PubMed and SCOPUS was conducted, using a set of inclusion and exclusion criteria. Risk of bias, quality of evidence and the strength of evidence were assessed for each included study.

Discussion: Six studies were ultimately included, 3 of which assessed NE as the outcome and 4 studies assessed DM as the outcome (1 study overlap). The quality of evidence was rated as “Moderate” for NE and “Low” for DM studies. Limited evidence of a statistically significant result was seen for the NE association, while a consistent statistically insignificant result was seen for the DM association.

Conclusion: This Navigation Guide based systematic literature review illustrated a “limited evidence of human toxicity” for the NE outcome and glyphosate while “insufficient evidence of human toxicity” was assessed for glyphosate and the DM outcome.