Department of Biomedical Engineering Posters and Presentations
Acoustic vaporization threshold of lipid coated perfluoropentane droplets
Document Type
Poster
Keywords
biomedical acoustics, droplet vaporization, tumor imaging, microbubbles
Publication Date
4-2017
Abstract
Phase shift droplets that can be vaporized in situ by acoustic stimulation offer a number of advantages over microbubbles as contrast agents due to their higher stability and smaller size distribution. They have potential applications in tumor imaging and drug delivery. The acoustic vaporization threshold (ADV) of droplets with perfluoropentane (PFP) core has been investigated extensively via optical and acoustical means. However, there are noticeable discrepancies among reported ADV thresholds between the two methods. In this study, we thoroughly discuss the criteria and the experimental methodology of determining the ADV threshold. In addition, we explain the possible reasons for the discrepancies between the optical and acoustical studies of the droplet vaporization. The ADV threshold was measured as a function of the excitation frequency by examining the scattered signal from PFP droplets (400-3000nm). The threshold increases with frequency2 MPa at 2.25 MHz, 2.5 MPa at 5 MHz and 3 MPa at 10 MHz. The scattered response from droplets was also compared with the scattered response from a microbubble at the corresponding excitation pressure and frequency. We found the ADV threshold to increase with frequency. The ADV threshold values determined here are in agreement with past values obtained using an optical technique.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Open Access
1
Acoustic vaporization threshold of lipid coated perfluoropentane droplets
Phase shift droplets that can be vaporized in situ by acoustic stimulation offer a number of advantages over microbubbles as contrast agents due to their higher stability and smaller size distribution. They have potential applications in tumor imaging and drug delivery. The acoustic vaporization threshold (ADV) of droplets with perfluoropentane (PFP) core has been investigated extensively via optical and acoustical means. However, there are noticeable discrepancies among reported ADV thresholds between the two methods. In this study, we thoroughly discuss the criteria and the experimental methodology of determining the ADV threshold. In addition, we explain the possible reasons for the discrepancies between the optical and acoustical studies of the droplet vaporization. The ADV threshold was measured as a function of the excitation frequency by examining the scattered signal from PFP droplets (400-3000nm). The threshold increases with frequency2 MPa at 2.25 MHz, 2.5 MPa at 5 MHz and 3 MPa at 10 MHz. The scattered response from droplets was also compared with the scattered response from a microbubble at the corresponding excitation pressure and frequency. We found the ADV threshold to increase with frequency. The ADV threshold values determined here are in agreement with past values obtained using an optical technique.
Comments
To be presented at GW Annual Research Days 2017.