Title

The path of least resistance: aggressive or moderate treatment?

Document Type

Journal Article

Publication Date

11-7-2014

Journal

Proceedings. Biological Sciences

Volume

281

Issue

1794

Inclusive Pages

20140566

Keywords

Anti-Infective Agents--administration & dosage; Biological Evolution; Drug Resistance, Microbial--genetics; Infection--drug therapy

Abstract

The evolution of resistance to antimicrobial chemotherapy is a major and growing cause of human mortality and morbidity. Comparatively little attention has been paid to how different patient treatment strategies shape the evolution of resistance. In particular, it is not clear whether treating individual patients aggressively with high drug dosages and long treatment durations, or moderately with low dosages and short durations can better prevent the evolution and spread of drug resistance. Here, we summarize the very limited available empirical evidence across different pathogens and provide a conceptual framework describing the information required to effectively manage drug pressure to minimize resistance evolution.

Comments

This is an open access PubMed Central article. Click on link for full-text access.

Peer Reviewed

1

Open Access

1