Haptoglobin Genotype and the Rate of Renal Function Decline in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

Authors

Trevor J. OrchardFollow
Wanjie SunFollow
Patricia A. Cleary, George Washington UniversityFollow
Saul M. Genuth
John M. Lachin, George Washington UniversityFollow
Paula McGee
Andrew D. Paterson
Philip Raskin
Yefim Anbinder
Andrew P. Levy
DCCT/EDIC Research Group

Document Type

Journal Article

Publication Date

9-2013

Journal

Diabetes Care

Volume

Volume 62, Issue 9

Inclusive Pages

3218–3223

Abstract

Many patients with type 1 diabetes develop renal disease despite moderately good metabolic control, suggesting other risk factors may play a role. Recent evidence suggests that the haptoglobin (HP) 2-2 genotype, which codes for a protein with reduced antioxidant activity, may predict renal function decline in type 1 diabetes. We examined this hypothesis in 1,303 Caucasian participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. HP genotype was determined by polyacrylamide gel electrophoresis. Glomerular filtration rate was estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and albumin excretion based on timed urine samples. Participants were followed up for a mean of 22 years. HP genotype was significantly associated with the development of sustained estimated glomerular filtration rate (GFR) <60 mL/min/1.73 m2and with end-stage renal disease (ESRD), with HP 2-2 having greater risk than HP 2-1 and 1-1. No association was seen with albuminuria. Although there was no treatment group interaction, the associations were only significant in the conventional treatment group, where events rates were much higher. We conclude that the HP genotype is significantly associated with the development of reduced GFR and ESRD in the DCCT/EDIC study.

Comments

Reproduced with permission of the American Diabetes Association. Diabetes Care.

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

APA Citation

Orchard, T. J., Sun, W., Cleary, P. A., Genuth, S. M., Lachin, J. M., et al. (2013). Haptoglobin Genotype and the Rate of Renal Function Decline in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study. Diabetes, 62(9), 3218–3223. doi:10.2337/db13-0256

Peer Reviewed

1

Open Access

1