Prognostic value of lymphocyte vascular density and e-cadherin in inflammatory breast cancer

Authors

Paul H. Levine, George Washington UniversityFollow
Heather J. Hoffman, George Washington UniversityFollow
Audra MacNeil, George Washington University
Salman Hashmi, George Washington University
Sherry X. Yang, National Cancer Institute
Stephen Hewitt, National Cancer Institute
Kenneth L. van Golen, University of Delaware
Sandra M. Swain, MedStar Washington Hospital Center, Washington, DC

Document Type

Journal Article

Publication Date

12-2014

Journal

Journal of Cancer Therapy

Volume

Volume 5, Issue 14

Inclusive Pages

1380-1387

Abstract

Background: We recently evaluated four laboratory assays, vascular endothelial growth factor D (VEGF-D), E-cadherin, lymphatic vessel density (LVD) measured by podoplanin, and intra-lymphatic tumor emboli (ILTE), which showed notable differences between inflammatory breast cancer (IBC) and non-inflammatory locally advanced breast cancer (LABC). In this study we investigated the potential of the three most quantitatively measured markers, E-cadherin, LVD and VEGF-D, to predict survival in the IBC patients.

Materials and Methods: This study involved the 100 cases identified in the Inflammatory Breast Cancer Registry (IBCR) whose tumors were previously evaluated for the four assays noted above. Living patients were recontacted and survival data were available for up to 17 years. Overall survival (OS) was analyzed through the Kaplan-Meier method stratified by E-cadherin, LVD, VEGF-D, and response to chemotherapy. The differences in OS curves were compared using the log-rank test.

Results: The median OS for patients with high LVD was 6.63 years (95% CI: 4.06 to 10.14), compared to median at 10 years not reached in those with low LVD (p = 0.03). There was a trend towards a longer median OS in patients with high E-cadherin (10.14, 95% CI: 6.63 to 11.67), compared with those with low E-cadherin (6.26, 95% CI: 3.42 to undeterminable). VEGF-D levels showed no correlation with survival.

Conclusion: Low LVD significantly predicts better survival. High E-cadherin expression, as with non-IBC breast cancer and several other malignancies, tends to be associated with a better prognosis.

Comments

Reproduced with permission of Scientific Research Publishing, Inc. (SCIRP). Journal of Cancer Therapy.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

APA Citation

Levine, L.H., Hoffman, H.J., MacNeil, A., Hashmi, S., Yang, S.X. et al. (2014). Prognostic value of lymphocyte vascular density and e-cadherin in inflammatory breast cancer. Journal of Cancer Therapy, 5(14), 1380-1387.

Peer Reviewed

1

Open Access

1