Microfluidic-enabled liposomes elucidate size-dependent transdermal transport

Authors

Renee R. Hood, University of Maryland, College Park
Eric L. Kendall, University of Maryland, College Park
Mariana Junqueira, Children's National Medical Center
Wyatt N. Vreeland, National Institute of Standards and Technology, Gaithersburg, MD
Zenaide M.N. Quezado, George Washington UniversityFollow
Julia C. FInkel, George Washington UniversityFollow
Don L. DeVoe, University of Maryland, College Park

Document Type

Journal Article

Publication Date

3-21-2014

Journal

PLoS ONE

Volume

Volume 9, Issue 3

Inclusive Pages

Article number e92978

Keywords

Liposomes--pharmacokinetics; Microfluidics; Skin--metabolism

Abstract

Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from deeper skin layers past the stratum corneum, the primary barrier to nanoparticle transport, liposomes with mean diameters between 31–41 nm exhibit significantly enhanced penetration. Furthermore, multicolor fluorescence imaging reveals that the smaller liposomes pass rapidly through the stratum corneum without vesicle rupture. These findings reveal that nanoscale liposomes with well-controlled size and minimal size variance are excellent vehicles for transdermal delivery of functional nanoparticle drugs.

Comments

Reproduced with permission of PLoS ONE.

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

APA Citation

Hood, R.R., Kendall, E.L., Junqueira, M., Vreeland, W.N., Quezado, Z. et al. (2014). Microfluidic-enabled liposomes elucidate size-dependent transdermal transport. PLoS ONE, 9(3):e92978.

Peer Reviewed

1

Open Access

1