Document Type
Journal Article
Publication Date
2016
Journal
Biomed Research International
Inclusive Pages
Article ID 1974972
DOI
10.1155/2016/1974972
Abstract
Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using the same vancomycin dosing regimens and confirming similarity in clinical characteristics, vancomycin trough concentrations measured by PETINIA (2011-2012, n = 400) were 20% lower and the mean difference was 1.93 mg/L compared to COBAS (2012–2014, n =352 ) measurements. The impact of vancomycin immunoassays in neonatal matrix was hereby suggested, supporting a switch to more advanced techniques (LC-MS/MS).
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Samardzic, J., Smits, A., Spriet, I., Soldatovic, I., Atkinson, A., Bajcetic, M., van den Anker, J. N., & Allegaert, K. (2016). Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates. Biomed Research International, (). http://dx.doi.org/10.1155/2016/1974972
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of HIndawi Publishing Corp. BioMed Research International