Document Type
Journal Article
Publication Date
2014
Journal
Immunotargets and Therapy
Volume
3
Inclusive Pages
97-106
DOI
10.2147/ITT.S40082
Abstract
Anti-pathogen adoptive T-cell immunotherapy has been proven to be highly effective in preventing or controlling viral infections following hematopoietic stem cell transplantation. Recent advances in manufacturing protocols allow an increased number of targeted pathogens, eliminate the need for viral transduction, broaden the potential donor pool to include pathogen-naïve sources, and reduce the time requirement for production. Early studies suggest that anti-fungal immunotherapy may also have clinical benefit. Future advances include further broadening of the pathogens that can be targeted and development of T-cells with resistance to pharmacologic immunosuppression.
APA Citation
Keller, M., & Bollard, C. M. (2014). Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation. Immunotargets and Therapy, 3 (). http://dx.doi.org/10.2147/ITT.S40082
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of Dove Press Ltd. Immunotargets and Therapy.