Document Type
Journal Article
Publication Date
12-1-2015
Journal
Molecular Genetics and Metabolism Reports
Volume
5
Inclusive Pages
103-106
DOI
10.1016/j.ymgmr.2015.11.001
Abstract
In mucopolysaccharidoses (MPS), glycosaminoglycans (GAG) accumulate in tissues. In MPS II, approximately two-thirds of patients are cognitively impaired. We investigated levels of GAG in cerebrospinal fluid (CSF) in different populations from four clinical studies (including NCT00920647 and NCT01449240). Data indicate that MPS II patients with cognitive impairment have elevated levels of CSF GAG, whereas those with the attenuated phenotype typically have levels falling between those of the cognitively affected patients and healthy controls.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Hendriksz, C., Muenzer, J., Vanderver, A., Davis, J., Burton, B., Mendelsohn, N., Wang, N., Pan, L., Pano, A., & Barbier, A. (2015). Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment.. Molecular Genetics and Metabolism Reports, 5 (). http://dx.doi.org/10.1016/j.ymgmr.2015.11.001
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of Elsevier B.V. Molecular Genetics and Metabolism Reports