Spatial correspondence of cortical activity measured with whole head fNIRS and fMRI: Toward clinical use within subject

Anthony Zinos, Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA.
Julie C. Wagner, Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA.
Scott A. Beardsley, Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI, USA; Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: scott.beardsley@marquette.edu.
Wei-Liang Chen, Center for Neuroscience Research, Children's National Medical Center, George Washington University, Washington DC, USA.
Lisa Conant, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Marsha Malloy, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Neurology, Children's Wisconsin, Milwaukee, WI, USA.
Joseph Heffernan, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Brendan Quirk, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Robert Prost, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Mohit Maheshwari, Department of Radiology, Children's Wisconsin, Milwaukee, WI, USA.
Jeffrey Sugar, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Harry T. Whelan, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Neurology, Children's Wisconsin, Milwaukee, WI, USA.

Document Type

Journal Article

Publication Date

4-15-2024

Journal

NeuroImage

Volume

290

DOI

10.1016/j.neuroimage.2024.120569

Keywords

DOT; Functional cortical activity; Motor cortex; Visual cortex; fMRI; fNIRS

Abstract

Functional near infrared spectroscopy (fNIRS) and functional magnetic resonance imaging (fMRI) both measure the hemodynamic response, and so both imaging modalities are expected to have a strong correspondence in regions of cortex adjacent to the scalp. To assess whether fNIRS can be used clinically in a manner similar to fMRI, 22 healthy adult participants underwent same-day fMRI and whole-head fNIRS testing while they performed separate motor (finger tapping) and visual (flashing checkerboard) tasks. Analyses were conducted within and across subjects for each imaging approach, and regions of significant task-related activity were compared on the cortical surface. The spatial correspondence between fNIRS and fMRI detection of task-related activity was good in terms of true positive rate, with fNIRS overlap of up to 68 % of the fMRI for analyses across subjects (group analysis) and an average overlap of up to 47.25 % for individual analyses within subject. At the group level, the positive predictive value of fNIRS was 51 % relative to fMRI. The positive predictive value for within subject analyses was lower (41.5 %), reflecting the presence of significant fNIRS activity in regions without significant fMRI activity. This could reflect task-correlated sources of physiologic noise and/or differences in the sensitivity of fNIRS and fMRI measures to changes in separate (vs. combined) measures of oxy and de-oxyhemoglobin. The results suggest whole-head fNIRS as a noninvasive imaging modality with promising clinical utility for the functional assessment of brain activity in superficial regions of cortex physically adjacent to the skull.

Department

Neurology

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