Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics

Authors

Volker Gerke, Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation (ZMBE), University of Münster, Von-Esmarch-Strasse 56, Münster, Germany. gerke@uni-muenster.de.
Felicity N. Gavins, Department of Life Sciences, Centre for Inflammation Research and Translational Medicine (CIRTM), Brunel University London, Uxbridge, UK.
Michael Geisow, The National Institute for Medical Research, Mill Hill, London, UK.
Thomas Grewal, School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Jyoti K. Jaiswal, Center for Genetic Medicine Research, Children's National Research Institute, Children's National Research and Innovation Campus, Washington, DC, USA.
Jesper Nylandsted, Danish Cancer Institute, Strandboulevarden 49, Copenhagen, Denmark.
Ursula Rescher, Research Group Cellular Biochemistry, Institute of Molecular Virology, Center for Molecular Biology of Inflammation (ZMBE), University of Münster, Von-Esmarch-Strasse 56, Münster, Germany. rescher@uni-muenster.de.

Document Type

Journal Article

Publication Date

2-21-2024

Journal

Nature communications

Volume

15

Issue

1

DOI

10.1038/s41467-024-45954-0

Abstract

Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca levels. Through this they act as Ca-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.

APA Citation

Gerke, Volker; Gavins, Felicity N.; Geisow, Michael; Grewal, Thomas; Jaiswal, Jyoti K.; Nylandsted, Jesper; and Rescher, Ursula, "Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics" (2024). GW Authored Works. Paper 4323.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4323

Department

Genomics and Precision Medicine