Milken Institute School of Public Health Poster Presentations (Marvin Center & Video)
Increased Risk of Renal Cell Carcinoma Following Exposure to Metalworking Fluids Among Autoworkers
Poster Number
38
Document Type
Poster
Publication Date
3-2016
Abstract
Objectives: Metalworking fluids (MWF), used to cool and lubricate metal in occupational settings, have been linked to several cancers but data on kidney cancer is limited. MWF is generally classified as of straight (neat or mineral oils), soluble (mixture of oil and water-based), and synthetic (water-based, no oil), reflecting different compositions over time and for different operations. We examined how oil- and water-based MWF influenced rate of kidney cancer overall and renal cell carcinoma (RCC) specifically.
Methods: From a cohort of Michigan autoworkers, 33,421 subjects were eligible for follow-up between 1985 and 2009. The cohort was linked to the National Death Index and the Michigan Cancer Registry, which identified new cases of kidney cancer and histologically confirmed RCC. We analyzed all kidney cancer and RCC alone in relation to cumulative exposure to each specific type of MWF, with a 15-year lag. Penalized splines with Cox Proportional Hazards Regression were used to estimate Hazard Ratios (HRs) and 95% confidence intervals (95% CIs), controlling for age, gender, race, calendar year, year hired, time since hire, plant, and other MWF types.
Results: There were 135 incident cases (83 RCC). A linear increase in the log-HR was observed for kidney cancer incidence with increasing cumulative exposure to each type separately and for all three types pooled into a single variable. The association was strongest for White males and RCC specifically. At the mean cumulative exposure to total MWF exposure, the estimated HR was 1.11 (95% CI 1.04, 1.19) for kidney cancer and 1.16 (95% CI 1.05, 1.27) for RCC only.
Conclusions: Our results signal a dose-dependent association between all types of MWF and kidney cancer and the RCC histologic type, although the influence of possible components in MWF needs to be determined. The better understanding of components and contaminants of MWF as well as molecular indicators of kidney damage that better define pathways leading to kidney cancer deserves further research.
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Open Access
1
Increased Risk of Renal Cell Carcinoma Following Exposure to Metalworking Fluids Among Autoworkers
Objectives: Metalworking fluids (MWF), used to cool and lubricate metal in occupational settings, have been linked to several cancers but data on kidney cancer is limited. MWF is generally classified as of straight (neat or mineral oils), soluble (mixture of oil and water-based), and synthetic (water-based, no oil), reflecting different compositions over time and for different operations. We examined how oil- and water-based MWF influenced rate of kidney cancer overall and renal cell carcinoma (RCC) specifically.
Methods: From a cohort of Michigan autoworkers, 33,421 subjects were eligible for follow-up between 1985 and 2009. The cohort was linked to the National Death Index and the Michigan Cancer Registry, which identified new cases of kidney cancer and histologically confirmed RCC. We analyzed all kidney cancer and RCC alone in relation to cumulative exposure to each specific type of MWF, with a 15-year lag. Penalized splines with Cox Proportional Hazards Regression were used to estimate Hazard Ratios (HRs) and 95% confidence intervals (95% CIs), controlling for age, gender, race, calendar year, year hired, time since hire, plant, and other MWF types.
Results: There were 135 incident cases (83 RCC). A linear increase in the log-HR was observed for kidney cancer incidence with increasing cumulative exposure to each type separately and for all three types pooled into a single variable. The association was strongest for White males and RCC specifically. At the mean cumulative exposure to total MWF exposure, the estimated HR was 1.11 (95% CI 1.04, 1.19) for kidney cancer and 1.16 (95% CI 1.05, 1.27) for RCC only.
Conclusions: Our results signal a dose-dependent association between all types of MWF and kidney cancer and the RCC histologic type, although the influence of possible components in MWF needs to be determined. The better understanding of components and contaminants of MWF as well as molecular indicators of kidney damage that better define pathways leading to kidney cancer deserves further research.
Comments
Presented at: GW Research Days 2016