Title

Rapid detection of malaria parasites in blood by high throughput laser desorption mass spectrometry

Document Type

Conference Proceeding

Publication Date

12-1-2002

Journal

Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics

Abstract

High throughput laser desorption (LD) mass spectrometry was used to study the rapid detection of malaria parasites in blood. The LD mass spectra of intact heme contained a series of structure-specific ions and signal intensities were quantitatively correlated with the sample parasitemia. Pulsed ion extraction was optimized for ion focusing and transmission at m/z 1200. A unique time of flight (TOF) multi-array system for increasing the throughput of blood screening for malaria was tested by simultaneous acquisition and analysis of multiple mass spectra.

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