Prostate cancer: A correlative study of Multiparametric MR imaging and digital histopathology
© RSNA, 2017. Purpose: To correlate multiparametric magnetic resonance (MR) imaging and quantitative digital histopathologic analysis (DHA) of the prostate. Materials and Methods: This retrospective study was approved by the local institutional review board and was HIPAA compliant. Forty patients (median age, 60 years; age range, 44-71 years) who underwent prostate MR imaging consisting of T2-weighted and diffusion-weighted (DW) MR imaging along with subsequent robot-assisted radical prostatectomy gave informed consent to be included. Whole-mount tissue specimens were obtained with a patient-specific mold, and DHA was performed to assess the lumen, epithelium, stroma, and epithelial nucleus. These DHA images were registered with MR images and were correlated on a pervoxel basis. The relationship between MR imaging and DHA was assessed by using a linear mixed-effects model and the Pearson correlation coefficient. Results: T2-weighted MR imaging, apparent diffusion coefficient (ADC) of DW imaging, and high-b-value DW imaging were significantly related to specific DHA parameters (P < .01). For instance, lumen density (ie, the percentage area of tissue components) was associated with T2-weighted MR imaging (slope = 0.36 ± 0.05 [standard error], γ = 0.35), ADC (slope = 0.47 ± 0.05, γ = 0.50), and high-b-value DW imaging (slope = 20.44 ± 0.05, γ = 20.44). Differences between regions harboring benign tissue and those harboring malignant tissue were observed at MR imaging and DHA (P , .01). Gleason score was significantly associated with MR imaging and DHA parameters (P , .05). For example, it was positively related to high-b-value DW imaging (slope = 0.21 ± 0.16, γ = 0.18) and negatively related to lumen density (slope = 20.19 ± 0.18, γ = 20.35). Conclusion: Overall, significant associations were observed between MR imaging and DHA, regardless of prostate anatomy.
Kwak, J., Sankineni, S., Xu, S., Turkbey, B., Choyke, P., Pinto, P., Moreno, V., Merino, M., & Wood, B. (2017). Prostate cancer: A correlative study of Multiparametric MR imaging and digital histopathology. Radiology, 285 (1). http://dx.doi.org/10.1148/radiol.2017160906