Title

Semiquantitative and quantitative analyses of dynamic contrast-enhanced magnetic resonance imaging of thyroid nodules

Document Type

Journal Article

Publication Date

1-1-2015

Journal

Journal of Computer Assisted Tomography

Volume

39

Issue

6

DOI

10.1097/RCT.0000000000000304

Keywords

Dynamic contrast enhancement MRI; Preoperative workup; Quantitative analysis; Semiquantitative analysis; Thyroid; Thyroid nodule evaluation

Abstract

© 2015 Wolters Kluwer Health, Inc. All rights reserved. Objective: This study was aimed to determine the utility of quantitative dynamic contrast-enhanced magnetic resonance imaging (MRI) in differentiating benign and malignant lesions in patients with known thyroid gland lesions scheduled for resection. Methods: Patients scheduled for resection of a thyroid mass were prospectively enrolled. Dynamic contrast-enhanced MRI scans of the neck were performed before surgery. After resection, patients were divided into benign and malignant groups. Quantitative and semiquantitative MRI kinetic measurements of benign and malignant lesions were compared and analyzed. Results: Twelve benign and 9 malignant lesions were identified in 19 patients. Mean Ktrans, Ve, and Kep for benign lesions were 1.69 ± 1.59 min-1, 0.44 ± 0.21 min-1, and 4.51 ± 2.96 min-1, respectively; for the malignant lesions, 0.96 ± 0.57 min-1, 0.45 ± 0.19 min-1, and 3.57 ± 3.53 min-1, respectively (P = 0.1886, 0.8036, and 0.3028, respectively). Tpeak, ERmax, slopemax, and iAUGC60 for benign lesions were 7.00 ± 8.09 seconds, 293.27 ± 141.25 seconds, 76.45 ± 65.80 seconds, and 63.46 ± 46.84, respectively; for malignant lesions, 8.11 ± 8.55 seconds, 227.6 ± 113.37 seconds, 81.17 ± 109.71 seconds, and 43.69 ± 26.19, respectively (P = 0.7525, 0.4941, 0.4474, and 0.3028, respectively). Conclusions: Dynamic contrast-enhanced MRI pattern of kinetics was not significantly different for benign and malignant lesions of the thyroid using quantitative or semiquantitative methods.

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