Title

Improved multislice perfusion imaging with velocity-selective arterial spin labeling

Document Type

Journal Article

Publication Date

1-1-2015

Journal

Journal of Magnetic Resonance Imaging

Volume

41

Issue

5

DOI

10.1002/jmri.24652

Keywords

arterial spin labeling; ASL; multislice; velocity-selective arterial spin labeling; VS-ASL

Abstract

© 2014 Wiley Periodicals, Inc. © 2014 Wiley Periodicals, Inc. Purpose To improve the multislice performance of velocity-selective arterial spin labeling (VS-ASL) imaging for cerebral blood flow (CBF) measurement such that it might be routinely applied for clinical applications with whole brain coverage. Materials and Methods VS-ASL was performed with improvements such as timing optimization, stimulated echo removal, and slice profile sharpening. Each improvement was evaluated in volunteers by measuring temporal noise in the CBF measurement. VS-ASL with all these improvements was performed in 20 patients with Moyamoya disease some of whom also underwent xenon-enhanced CT (xeCT) imaging which was the reference standard for CBF measurement. Results Sequence timing optimization and inter-slice crosstalk reduction using stimulated echo removal and slice profile sharpening all contributed to reduction of temporal noise. VS-ASL imaging with all these improvements performed in Moyamoya disease patients showed significant reduction of temporal noise (P<0.0001) and increased correlation coefficient with xeCT CBF imaging (from 0.07 to 0.62). Conclusion We demonstrated that timing optimization, stimulated echo removal, and slice profile improvement have a large effect on image quality and robustness of VS-ASL in clinical imaging applications. J. Magn. Reson. Imaging 2015;41:1422-1431.

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