Spontaneous activity of morphologically identified ganglion cells in the developing ferret retina
Journal of Neuroscience
Dual patch-clamp; Ganglion cells; Retina; Retinal development; Spontaneous activity; Synchronous activity
Whole-cell patch-clamp recordings were made from morphologically identified ganglion cells in the intact retina of developing ferrets. As early as 3 d after birth, all ganglion cells exhibited bursts of spontaneous activity, with the interval between bursts gradually decreasing with maturity. By 2 weeks after birth, ganglion cells could be morphologically differentiated into three major classes (α, β, and γ), and at this time each cell class was characterized by a distinct pattern of spontaneous activity. Dual patch-clamp recordings from pairs of neighboring cells revealed that cells of all morphological classes burst in a coordinated manner, regardless of cell type. These observations suggest that a common mechanism underlies the bursting patterns exhibited by all ganglion cell classes, and that class-specific firing patterns emerge coincident with retinal ganglion cell morphological differentiation.
Liets, L., Olshausen, B., Wang, G., & Chalupa, L. (2003). Spontaneous activity of morphologically identified ganglion cells in the developing ferret retina. Journal of Neuroscience, 23 (19). http://dx.doi.org/10.1523/jneurosci.23-19-07343.2003