Cervical spine degenerative disease is an independent risk factor for increased revision rate following total knee arthroplasty

Document Type

Journal Article

Publication Date



European Journal of Orthopaedic Surgery and Traumatology




Cervical degenerative disease; Revision rates; Total knee arthroplasty


© 2020, Springer-Verlag France SAS, part of Springer Nature. Introduction: The relationship between cervical degenerative pathology and total knee arthroplasty (TKA) revision rates is not well understood. The aim of the study was to determine whether cervical spine degenerative diseases have a role in complications following TKA within 2 years. Methods: Data were collected from the Humana insurance database using the PearlDiver Patient Records Database from 2007–2017. Patients who had a primary TKA were identified using Current Procedural Terminology (CPT) code 27,447, and patients with degenerative cervical disease were identified using CPT and International Classification of Diseases (ICD) codes. Data on patients’ demographics, comorbidities and postoperative complications were recorded and analyzed with univariate and multivariate analysis with significance set at p < 0.05. A Kaplan–Meier analysis was conducted to estimate the 1- and 2-year rates of survival free from revision. Results: A total of 81,873 patients were included in this study. Following multivariate analysis, cervical spine degenerative disease patients were at increased risk of all-cause revision surgery following 1 year (OR: 1.342 95% CI: 1.149–1.569; p < 0.001) and 2 year (OR: 1.338; 95% CI: 1.184–1.512; p < 0.001). At 2 years, patients with cervical spine degenerative disease had a survival rate of 97.7%, while the survival rate was 99.2% among the non-cervical degenerative cohort. Conclusions: Based on these results, patients with cervical spine degenerative pathology should be counseled that their spinal pathology may impair outcomes following TKA.