Title

Invasive aspergillosis in patients with hiv infection: Report of two patients and a review of the literature

Document Type

Journal Article

Publication Date

1-1-1991

Journal

Journal of Acquired Immune Deficiency Syndromes

Volume

4

Issue

6

Keywords

Aspergillosis; HIV

Abstract

Summary: Two cases of invasive aspergillosis in AIDS patients are reported and previously reported AIDS-related cases are reviewed. Only one-half of all cases were diagnosed antemortem. Outcome is poor despite antifungal and surgical therapy. Normal phagocytic function is important in host defense against Aspergillus species. HIV-infected patients may have impaired phagocytic function as a result of antiretroviral therapy or treatment of opportunistic infection, or due to HIV infection itself. As the lifespans of HIV-infected patients are extended by antiretroviral therapy, an increasing awareness of Aspergillus infection as an opportunistic pathogen will be necessary. © 1991 Raven Press, New York.

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