Title

Factors involved in destabilization of atherosclerotic plaques

Document Type

Journal Article

Publication Date

12-1-1995

Journal

Journal of Myocardial Ischemia

Volume

7

Issue

6

Abstract

Recent studies are beginning to clarify some of the processes involved in rapid progression and destabilization of atherosclerotic plaques. Studies of atherectomy specimens suggest that free radical-derived oxidants and plasminogen activator inhibitor type 1 (PAI-1) may play a pathogenetic role in unstable ischemic syndromes. Also, recent reports linking angiotensin-converting enzyme (ACE) gene polymorphism with increased risk of myocardial infarction (MI) must be clarified, particularly with regard to its significance in women. Finally, data from the Asymptomatic Cardiac Ischemia Pilot (ACIP) study raise the possibility that ischemic episodes detected by continuous ambulatory ECG (AECG) monitoring may provide a simple clinical marker for plaque instability. All these findings suggest that it may be possible to identify biochemical or functional abnormalities associated with early atherosclerotic vascular disease.

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