MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells
Doklady Biochemistry and Biophysics
© 2018, Pleiades Publishing, Ltd. Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor (IGF1R) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells.
Tarasov, V., Tyutyakina, M., Makhotkin, M., Shin, E., Naboka, A., Mashkarina, A., Chebotarev, D., Cherkasova, E., Kogan, M., Chibichyan, M., & Matishov, D. (2018). MicroRNA-Dependent Regulation of IGF1R Gene Expression in Hormone-Sensitive and Hormone-Resistant Prostate Cancer Cells. Doklady Biochemistry and Biophysics, 479 (1). http://dx.doi.org/10.1134/S1607672918020138