Title

β 1, 4-oligoglucosides inhibit the binding of aspergillus fumigatus conidia to human monocytes

Document Type

Journal Article

Publication Date

1-1-1991

Journal

Journal of Infectious Diseases

Volume

163

Issue

5

DOI

10.1093/infdis/163.5.1154

Abstract

The binding of Aspergillus fumigatus conidia to human monocytes is mediated by a barley βglucan-inhibitable receptor. The simplest linkages in this glucan are present in the disaccharides laminaribiose (β1, 3) and cellobiose (β1, 4). Although laminaribiose gave strong inhibition of conidial binding to monocytes, cellobiose and oligosaccharides with β1, 4-linked glucose residues were more potent as specific inhibitors of this binding over similar concentrations. Increasing the number of β1, 4-linked glucose residues led to greater inhibition of conidial binding by human monocytes. © 1991 by The University of Chicago.

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