Hypersensitivity to 5-ASA suppositories
Digestive Diseases and Sciences
allergy; fever; mesalamine; rash; suppository
A patient with severe proctosigmoiditis developed rash, fever, and hepatitis when treated with sulfasalazine. This patient subsequently was treated for a year with two therapeutic courses of 4-aminosalicylic (4-ASA) enemas with good response and no adverse effects. Five years later the patient was twice treated with mesalamine (5-ASA) suppositories and on both occasions immediately developed fever and rash. This is the first documentation of a patient allergic to 5-ASA suppositories who was able to take its isomer 4-ASA without an allergic reaction with good therapeutic response.
Borum, M., & Ginsberg, A. (1997). Hypersensitivity to 5-ASA suppositories. Digestive Diseases and Sciences, 42 (5). http://dx.doi.org/10.1023/A:1018857607739