Title

Hypersensitivity to 5-ASA suppositories

Document Type

Journal Article

Publication Date

6-19-1997

Journal

Digestive Diseases and Sciences

Volume

42

Issue

5

DOI

10.1023/A:1018857607739

Keywords

allergy; fever; mesalamine; rash; suppository

Abstract

A patient with severe proctosigmoiditis developed rash, fever, and hepatitis when treated with sulfasalazine. This patient subsequently was treated for a year with two therapeutic courses of 4-aminosalicylic (4-ASA) enemas with good response and no adverse effects. Five years later the patient was twice treated with mesalamine (5-ASA) suppositories and on both occasions immediately developed fever and rash. This is the first documentation of a patient allergic to 5-ASA suppositories who was able to take its isomer 4-ASA without an allergic reaction with good therapeutic response.

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