Junctional ectopic tachycardia (JET) and atrial fibrillation (AF) occur in patients recovering from open-heart surgery (OHS). Pharmacologic treatment is used for the control of post-operative atrial arrhythmias (POAA), but is associated with side effects. There is a need for a reversible, modulated solution to rate control. We propose a non-pharmacologic technique that can modulate AV nodal conduction in a selective fashion. Ten mongrel dogs underwent OHS. Stimulation of the anterior right (AR) and inferior right (IR) fat pad (FP) was done using a 7-pole electrode. The IR was more effective in slowing the ventricular rate (VR) to AF (52 +/- 20 vs. 15 +/- 10%, p = 0.003) and JET (12 +/- 7 vs. 0 +/- 0%, p = 0.02). Selective site stimulation within a FP region could augment the effect of stimulation during AF (57 +/- 20% (maximum effect) vs. 0 +/- 0% (minimum effect), p
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Mercader, M., He, D., Sharma, A., Marchitto, M., Trachiotis, G., Bornzin, G., Jonas, R. A., & Moak, J. (2017). Selective autonomic stimulation of the AV node fat pad to control rapid post-operative atrial arrhythmias.. PLoS One, 12 (9). http://dx.doi.org/10.1371/journal.pone.0183804