Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion

Charles A. Ishak, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Sajid A. Marhon, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Naïri Tchrakian, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Anjelica Hodgson, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Helen Loo Yau, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Isabela M. Gonzaga, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Melanie Peralta, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Ilinca M. Lungu, Diagnostic Development Program, Ontario Institute of Cancer Research, Toronto, Canada.
Stephanie Gomez, Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Sheng-Ben Liang, Princess Margaret Cancer Biobank, University Health Network, Toronto, Canada.
Shu Yi Shen, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Raymond Chen, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Jocelyn Chen, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Biji Chatterjee, Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas.
Kevin N. Wanniarachchi, Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas.
Junwoo Lee, Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas.
Nicholas Zehrbach, Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas.
Amir Hosseini, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Parinaz Mehdipour, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Siyu Sun, Department of Epidemiology and Biostatistics, Halvorsen Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Alexander Solovyov, Department of Epidemiology and Biostatistics, Halvorsen Center for Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ilias Ettayebi, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Kyle E. Francis, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Aobo He, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Taiyi Wu, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Shengrui Feng, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Tiago da Silva Medina, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Felipe Campos de Almeida, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Jane Bayani, Diagnostic Development Program, Ontario Institute of Cancer Research, Toronto, Canada.
Jason Li, Diagnostic Development Program, Ontario Institute of Cancer Research, Toronto, Canada.
Spencer MacDonald, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Yadong Wang, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Document Type

Journal Article

Publication Date

4-2-2025

Journal

Cancer discovery

Volume

15

Issue

4

DOI

10.1158/2159-8290.CD-24-0094

Abstract

Our landmark discovery of viral mimicry characterized repetitive elements as immunogenic stimuli that cull cancer cells. If expressed repetitive elements cull cancer cells, why does every human cancer express repetitive elements? Our report offers an exciting advancement toward understanding this paradox and how to exploit this mechanism for cancer interception. See related commentary by Murayama and Cañadas, p. 670.

Department

School of Medicine and Health Sciences Student Works

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