A Case of Rocuronium-Induced Anaphylaxis Managed With Sugammadex

Document Type

Journal Article

Publication Date

4-1-2025

Journal

Cureus

Volume

17

Issue

4

DOI

10.7759/cureus.81701

Keywords

anesthesia induction; drug induced anaphylaxis; peri-operative anaphylaxis; rocuronium induced anaphylaxis; sugammadex

Abstract

Anaphylaxis is a severe, life-threatening complication that can result in complete cardiovascular and respiratory collapse. Peri-operatively, this complication is most often seen after the intravenous (IV) induction of general anesthesia, and the most common responsible agents are non-depolarizing neuromuscular blocking agents. In this report, we describe a case of perioperative anaphylaxis induced by the non-depolarizing neuromuscular blocker rocuronium. Sugammadex, a reversal agent for the non-depolarizing muscle relaxants rocuronium and vecuronium, was administered shortly after induction. The patient showed rapid clinical improvement in blood pressure, heart rate, and oxygen saturation values within minutes of sugammadex administration. We suggest that sugammadex should be considered as an adjunct therapy when treating anaphylaxis caused by rocuronium.

Department

Anesthesiology and Critical Care Medicine

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