Molecular profiling of basal cell carcinoma of the prostate: A case report and literature review

Authors

Luca Bertozzi, The George Washington University School of Medicine and Health Sciences, 2300 I St NW, Washington, DC, 20052, USA.
Eileen Zhang, University of Maryland, 7901 Regents Drive, College Park, MD, 20742, USA.
Mohadese Behtaj, Department of Pathology, The George Washington Medical Faculty Associates, 2300 M Street NW, Suite 715, Washington, DC, 20037, USA.
Olivia Gordon, Department of Urology, The George Washington Medical Faculty Associates, 2150 Pennsylvania Ave NW, Suite 3-417, Washington, DC, 20037, USA.
Michael J. Whalen, Department of Urology, The George Washington Medical Faculty Associates, 2150 Pennsylvania Ave NW, Suite 3-417, Washington, DC, 20037, USA.

Document Type

Journal Article

Publication Date

5-1-2025

Journal

Urology case reports

Volume

60

DOI

10.1016/j.eucr.2025.102993

Keywords

Basal cell carcinoma; Molecular profiling; Prostate cancer

Abstract

Prostate basal cell carcinoma (BCC) is a rare pathologic variant with a poorly understood molecular profile. Here, we describe a case of prostate BCC and compare its genetic alterations to cases in the literature. After presenting with hematuria, our patient underwent definitive radical prostatectomy for his localized biopsy-proven BCC. Somatic and germline testing revealed mutations in PIK3R1, KMT2D, and NOTCH1, and MUTYH, NBN, and MSH3, respectively. Upon literature review, we found that prostate BCC mutations disrupt cell growth, epigenetic regulation, and cell fate determination. With no consensus guidelines available, experimental targeted therapies have shown promise for prostate BCC management.

APA Citation

Bertozzi, Luca; Zhang, Eileen; Behtaj, Mohadese; Gordon, Olivia; and Whalen, Michael J., "Molecular profiling of basal cell carcinoma of the prostate: A case report and literature review" (2025). GW Authored Works. Paper 6724.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/6724

Department

Pathology