Molecular profiling of basal cell carcinoma of the prostate: A case report and literature review
Document Type
Journal Article
Publication Date
5-1-2025
Journal
Urology case reports
Volume
60
DOI
10.1016/j.eucr.2025.102993
Keywords
Basal cell carcinoma; Molecular profiling; Prostate cancer
Abstract
Prostate basal cell carcinoma (BCC) is a rare pathologic variant with a poorly understood molecular profile. Here, we describe a case of prostate BCC and compare its genetic alterations to cases in the literature. After presenting with hematuria, our patient underwent definitive radical prostatectomy for his localized biopsy-proven BCC. Somatic and germline testing revealed mutations in PIK3R1, KMT2D, and NOTCH1, and MUTYH, NBN, and MSH3, respectively. Upon literature review, we found that prostate BCC mutations disrupt cell growth, epigenetic regulation, and cell fate determination. With no consensus guidelines available, experimental targeted therapies have shown promise for prostate BCC management.
APA Citation
Bertozzi, Luca; Zhang, Eileen; Behtaj, Mohadese; Gordon, Olivia; and Whalen, Michael J., "Molecular profiling of basal cell carcinoma of the prostate: A case report and literature review" (2025). GW Authored Works. Paper 6724.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/6724
Department
Pathology