Imaging Clusters of Pediatric Low-Grade Glioma are Associated with Distinct Molecular Characteristics

Anahita Fathi Kazerooni, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Adam Kraya, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Komal S. Rathi, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Meen Chul Kim, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Varun Kesherwani, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Ryan Corbett, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Arastoo Vossough, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Nastaran Khalili, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Deep Gandhi, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Neda Khalili Familiar, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Run Jin, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Xiaoyan Huang, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Yuankun Zhu, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Alex Sickler, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Matthew R. Lueder, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Saksham Phul, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Phillip B. Storm, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Jeffrey B. Ware, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Jessica B. Foster, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Sabine Mueller, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Jo Lynne Rokita, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Michael J. Fisher, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Adam C. Resnick, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.
Ali Nabavizadeh, From the Division of Neurosurgery (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S., M.R.L., S.P., P.B.S., A.C.R.,A.N.), Centre for Data-Driven Discovery in Biomedicine (Db) (A.F.K., A.K., K.R., M.C.K., V.K., N.K., A.M.F., R.J., N.K., D.G., X.H., Y.Z., A.S.,M.R.L., S.P., P.B.S., A.C.R., A.N.), Department of Radiology (A.V.), Department of Pathology and Laboratory Medicine (M.R.L.), Division of Oncology (J.B.F., M.J.F.), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Neurosurgery (A.F.K., P.B.S., A.C.R.), Department of Radiology (A.N., J.B.W.), Department of Pediatrics (J.B.F.), University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pediatrics (R.C., J.L.R.), The George Washington University, Washington, DC, USA; Department of Neurology and Pediatrics (S.M.), University of California San Francisco, San Francisco, CA, USA.

Document Type

Journal Article

Publication Date

2-14-2025

Journal

AJNR. American journal of neuroradiology

DOI

10.3174/ajnr.A8699

Abstract

BACKGROUND AND PURPOSE: Cancers show heterogeneity at various levels, from genome to radiological imaging. This study aimed to explore the interplay between genomic, transcriptomic, and radiophenotypic data in pediatric low-grade glioma (pLGG), the most common group of brain tumors in children. MATERIALS AND METHODS: We analyzed data from 201 pLGG patients in the Children's Brain Tumor Network (CBTN), using principal component analysis and K-Means clustering on 881 radiomic features, along with clinical variables (age, sex, tumor location), to identify imaging clusters and examine their association with 2021 WHO pLGG classifications. To determine the transcriptome pathways linked to imaging clusters, we employed a supervised machine learning model with elastic net logistic regression based on the pathways identified through gene set enrichment and gene co-expression network analyses. RESULTS: Three imaging clusters with distinct radiomic characteristics were identified. BRAF V600E mutations were primarily found in imaging cluster 3, while KIAA1549::BRAF fusion occurred in subtype 1. The model's predictive accuracy (AUC) was 0.77 for subtype 1, 0.78 for subtype 2, and 0.70 for subtype 3. Each imaging cluster exhibited unique molecular mechanisms: subtype 1 was linked to oxidative phosphorylation, PDGFRB, and interleukin signaling, whereas subtype 3 was associated with histone acetylation and DNA methylation pathways, related to BRAF V600E pLGGs. CONCLUSIONS: Our radiogenomics study indicates that the intrinsic molecular characteristics of tumors correlate with distinct imaging subgroups in pLGG, paving the way for future multi-modal investigations that may enhance understanding of disease progression and targetability. ABBREVIATIONS: WHO = World Health Organization; CBTN = Children's Brain Tumor Network; pLGG = pediatric Low-Grade Glioma; EFS = Event-Free Survival; PC = Principal Component; CNS = Central Nervous System.

Department

Pediatrics

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