Quantity of Caloric Support After Pediatric Severe Traumatic Brain Injury: Description of Associated Outcomes in a Single Retrospective Center Cohort, 2010-2022

Authors

Elizabeth C. Elliott, Department of Pediatrics, Division of Critical Care Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC.
Eduardo A. Trujillo-Rivera, Department of Pediatrics, Division of Critical Care Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC.
Omar Dughly, Department of Pediatrics, Division of Critical Care Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC.
Terry Dean, Department of Pediatrics, Division of Critical Care Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC.
Dana Harrar, Department of Pediatrics, Division of Neurology, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC.
Michael J. Bell, Department of Pediatrics, Division of Critical Care Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC.
Kitman Wai, Department of Pediatrics, Division of Critical Care Medicine, Children's National Hospital and The George Washington University School of Medicine and Health Sciences, Washington, DC.

Document Type

Journal Article

Publication Date

1-1-2025

Journal

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Volume

26

Issue

1

DOI

10.1097/PCC.0000000000003641

Abstract

OBJECTIVES: To examine the relationship between adequacy of caloric nutritional support during the first week after severe traumatic brain injury (TBI) and outcome. DESIGN: Single-center retrospective cohort, 2010-2022. SETTING: Tertiary care children's hospital with a level 1 trauma center. PATIENTS: Children younger than 18 years with PICU stay greater than 7 days for management of TBI, who had severe TBI, defined as Glasgow Coma Scale (GCS) score less than or equal to 8 at initial presentation and/or placement of an intracranial pressure monitor or external ventricular drain, and/or decompressive hemicraniectomy. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A total of 93 patients were identified (median age 46 mo; 53% male; median GCS 5; hospital mortality 4%). Caloric goal was assigned by a dietician and the proportion of prescribed calories delivered to each patient over the first 7 days of PICU admission were analyzed. At the end of the first 7 days post-injury, overall median (interquartile range [IQR]) caloric and protein adequacies were 42% (IQR, 28-62%) and 48% (IQR, 29-61%), respectively. We failed to identify an association between adequacy of caloric support and greater odds of higher Functional Status Scale (FSS) score or higher Glasgow Outcome Scale Extended for Pediatrics score at discharge. However, at outpatient follow-up, prior adequacy of PICU caloric support was associated with greater odds of worse FSS (multiplicative increase per 10% increase in calories [MI], 1.10; 95% CI, 1.03-1.18; p = 0.002) and worse GOS E-Peds (MI, 1.16; 95% CI, 1.08-1.27; p < 0.001) at outpatient follow-up. CONCLUSIONS: In pediatric patients with severe TBI, there is an association between delivery of a greater proportion of their goal calories during the first 7 days after injury and greater odds of worse outcome at outpatient follow-up.

APA Citation

Elliott, Elizabeth C.; Trujillo-Rivera, Eduardo A.; Dughly, Omar; Dean, Terry; Harrar, Dana; Bell, Michael J.; and Wai, Kitman, "Quantity of Caloric Support After Pediatric Severe Traumatic Brain Injury: Description of Associated Outcomes in a Single Retrospective Center Cohort, 2010-2022" (2025). GW Authored Works. Paper 6435.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/6435

Department

Pediatrics